Preferred Label : FGFR2 Inhibitor 3HP-2827;
NCIt definition : An orally bioavailable small molecule inhibitor of fibroblast growth factor receptor
2 (FGFR2), with potential antineoplastic activity. Upon oral administration, FGFR2
inhibitor 3HP-2827 targets, binds to and inhibits FGFR2, which results in the inhibition
of FGFR2-mediated signal transduction pathways. This may inhibit the proliferation
of tumor cells that harbor FGFR2 alterations, including amplifications, mutations
and fusions. FGFR2, a receptor tyrosine kinase upregulated and mutated in many tumor
cell types, plays a key role in cellular proliferation, migration and survival.;
Molecule name : 3HP-2827; 3HP 2827;
Origin ID : C209279;
concept_is_in_subset
- has_target
