" /> Alofanib - CISMeF





Preferred Label : Alofanib;

NCIt synonyms : Benzoic Acid, 3-(((4-Methyl-2-nitro-5-(3-pyridinyl)phenyl)amino)sulfonyl)-;

NCIt definition : An inhibitor of the fibroblast growth factor receptor (FGFR) type 2 (FGFR2), with potential antineoplastic and anti-angiogenic activities. Upon administration, alofanib targets, allosterically binds to the extracellular domain of FGFR2 and inhibits the activity of FGFR2, which may result in the inhibition of basic FGF (bFGF)/FGFR2-related signal transduction pathways. This inhibits FGF-induced endothelial cell proliferation and migration, and inhibits the proliferation of FGFR2-overexpressing tumor cells. FGFR2, a receptor tyrosine kinase upregulated in many tumor cell types, plays a key role in cellular proliferation, migration and survival.;

UNII : LQX7RFK8MZ;

InChIKey : QUQGQIASFYWKAB-UHFFFAOYSA-N;

CAS number : 1612888-66-0;

Molecule name : RPT 835; RPT-835; ES000835;

NCI Metathesaurus CUI : CL1383158;

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08/05/2025


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