Pan-FGFR Inhibitor LY2874455

Preferred Label : Pan-FGFR Inhibitor LY2874455;

NCIt synonyms : Pan FGFR Inhibitor LY2874455; Pan Fibroblast Growth Factor Receptor Inhibitor LY2874455;

NCIt related terms : LY-2874455;

NCIt definition : An orally bioavailable pan-inhibitor of fibroblast growth factor receptor (FGFR) family proteins, with potential antineoplastic activity. Upon oral administration, FGFR inhibitor LY2874455 binds to and inhibits FGFR subtypes 1 (FGFR1), 2 (FGFR2), 3 (FGFR3) and 4 (FGFR4), which results in the inhibition of FGFR-mediated signal transduction pathways. This inhibits both tumor angiogenesis and proliferation of FGFR-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases upregulated in many tumor cell types, plays a key role in cellular proliferation, cell survival and angiogenesis.;

UNII : E9M363811V;

CAS number : 1254473-64-7;

Molecule name : LY2874455;

NCI Metathesaurus CUI : CL433720;

Details

Origin ID

C139004;

UMLS CUI

C3490747;

Currated CISMeF NLP mapping
- LY2874455 [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- LY2874455 [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Fibroblast Growth Factor Receptor Family [NCIt concept]

Keyword's position in hierarchy(ies) :

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