" /> Ponatinib Hydrochloride - CISMeF





Preferred Label : Ponatinib Hydrochloride;

NCIt synonyms : Benzamide, 3-(2-Imidazo(1,2-B)Pyridazin-3-Ylethynyl)-4-Methyl-N-(4-((4-Methyl-1- Piperazinyl)Methyl)-3-(Trifluoromethyl)Phenyl)-, Hydrochloride (1:1); AP24534 HCl; Multitargeted Receptor Tyrosine Kinase Inhibitor AP24534;

NCIt definition : The hydrochloride salt form of an orally bioavailable multitargeted receptor tyrosine kinase (RTK) inhibitor with potential antiangiogenic and antineoplastic activities. Ponatinib inhibits unmutated and all mutated forms of Bcr-Abl, including T315I, the highly drug therapy-resistant missense mutation of Bcr-Abl. This agent also inhibits other tyrosine kinases including those associated with vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs); in addition, it inhibits the tyrosine kinase receptor TIE2 and FMS-related tyrosine kinase receptor-3 (Flt3). RTK inhibition by ponatinib may result in the inhibition of cellular proliferation and angiogenesis and may induce cell death. Bcr-Abl is a fusion tyrosine kinase encoded by the Philadelphia chromosome.;

UNII : 96R6PU3D8J;

InChIKey : BWTNNZPNKQIADY-UHFFFAOYSA-N;

CAS number : 1114544-31-8;

Drug name : Iclusig;

Chemical formula : C29H27F3N6O.ClH;

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30/05/2025


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