" /> Futibatinib - CISMeF





Preferred Label : Futibatinib;

NCIt synonyms : 2-Propen-1-one, 1-((3S)-3-(4-Amino-3-(2-(3,5-dimethoxyphenyl)ethynyl)-1H-pyrazolo(3,4-d)pyrimidin-1-yl)-1-pyrrolidinyl)-;

NCIt definition : An orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. Futibatinib selectively and irreversibly binds to and inhibits FGFR, which may result in the inhibition of both the FGFR-mediated signal transduction pathway and tumor cell proliferation, and increased cell death in FGFR-overexpressing tumor cells. FGFR is a receptor tyrosine kinase essential to tumor cell proliferation, differentiation and survival and its expression is upregulated in many tumor cell types.;

UNII : 4B93MGE4AL;

InChIKey : KEIPNCCJPRMIAX-HNNXBMFYSA-N;

CAS number : 1448169-71-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1448169-71-8 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Lytgobi;

Molecule name : TAS-120;

NCI Metathesaurus CUI : CL471791;

Codes from synonyms : 20248;

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16/05/2024


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