Pemigatinib - CISMeF

Preferred Label : Pemigatinib;

NCIt synonyms : 2H-Pyrrolo(3',2':5,6)pyrido(4,3-d)pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-8-(4-morpholinylmethyl)-;

NCIt definition : An orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) types 1, 2, and 3 (FGFR1/2/3), with potential antineoplastic activity. Pemigatinib binds to and inhibits FGFR1/2/3, which may result in the inhibition of FGFR1/2/3-related signal transduction pathways. This inhibits proliferation in FGFR1/2/3-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases upregulated in many tumor cell types, plays a key role in cellular proliferation, migration, and survival.;

UNII : Y6BX7BL23K;

InChIKey : HCDMJFOHIXMBOV-UHFFFAOYSA-N;

CAS number : 1513857-77-6;

Drug name : Pemazyre;

Molecule name : INCB-054828; INCB 054828;

Codes from synonyms : 13351;

Details

Origin ID

C121553;

UMLS CUI

C4724807;

Currated CISMeF NLP mapping
- Pemigatinib [SMS substance]
- Pemigatinib (substance) [SNOMED CT concept]
- pemigatinib [MeSH Supplementary Concept]
- pemigatinib [MeSH concept]
Manual BTNT mappings - CISMeF
- pemigatinib [ATC Code]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Pemigatinib (substance) [SNOMED CT concept]
- Product containing pemigatinib (medicinal product) [SNOMED CT concept]
- pemigatinib [MeSH Supplementary Concept]
- pemigatinib [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Fibroblast Growth Factor Receptor Family [NCIt concept]
is_component_of_chemotherapy_regimen
- Pemigatinib Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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