Preferred Label : Pemigatinib;
NCIt synonyms : 2H-Pyrrolo(3',2':5,6)pyrido(4,3-d)pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-8-(4-morpholinylmethyl)-;
NCIt definition : An orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) types
1, 2, and 3 (FGFR1/2/3), with potential antineoplastic activity. Pemigatinib binds
to and inhibits FGFR1/2/3, which may result in the inhibition of FGFR1/2/3-related
signal transduction pathways. This inhibits proliferation in FGFR1/2/3-overexpressing
tumor cells. FGFR, a family of receptor tyrosine kinases upregulated in many tumor
cell types, plays a key role in cellular proliferation, migration, and survival.;
UNII : Y6BX7BL23K;
InChIKey : HCDMJFOHIXMBOV-UHFFFAOYSA-N;
CAS number : 1513857-77-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1513857-77-6
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G-SRS /a ;
Drug name : Pemazyre;
Molecule name : INCB054828;
Codes from synonyms : 13351;
Origin ID : C121553;
UMLS CUI : C4724807;
Currated CISMeF NLP mapping
- Manual BTNT mappings - CISMeF
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
- is_component_of_chemotherapy_regimen
