Preferred Label : Pan-FGFR Inhibitor ABSK-121;
NCIt synonyms : FGFR Inhibitor ABSK-121; Pan-fibroblast Growth Factor Receptor Inhibitor ABSK-121;
NCIt definition : An orally bioavailable, small molecule pan-inhibitor of fibroblast growth factor receptor
(FGFR) family proteins, with potential antineoplastic activity. Upon oral administration,
pan-FGFR inhibitor ABSK-121 binds to and inhibits FGFR family proteins, including
FGFR2 and FGFR3 gatekeeper, molecular brake, and activation loop mutations. This prevents
FGFR-mediated signaling, and inhibits both tumor angiogenesis and proliferation of
FGFR-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases upregulated
in many tumor cell types, plays a key role in cellular proliferation, cell survival
and angiogenesis.;
Molecule name : ABSK-121-NX; ABSK-121; ABSK 121;
NCI Metathesaurus CUI : CL1905856;
Origin ID : C198696;
concept_is_in_subset
- has_target
