FGFR Inhibitor ASP5878

Preferred Label : FGFR Inhibitor ASP5878;

NCIt related terms : ASP-5878;

NCIt definition : An orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR), with potential antineoplastic activity. Upon oral administration, FGFR inhibitor ASP5878 binds to and inhibits FGFR, which results in the inhibition of FGFR-mediated signal transduction pathways. This inhibits proliferation in FGFR-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases upregulated in many tumor cell types, plays a key role in cellular proliferation and survival.;

UNII : C0Z095LL72;

CAS number : 1453208-66-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1453208-66-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : ASP5878;

NCI Metathesaurus CUI : CL471763;

Details

Origin ID

C122719;

UMLS CUI

C4053679;

Currated CISMeF NLP mapping
- ASP5878 [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ASP5878 [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Fibroblast Growth Factor Receptor Family [NCIt concept]

Keyword's position in hierarchy(ies) :

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