Receptor Tyrosine Kinase

Preferred Label : Receptor Tyrosine Kinase;

NCIt synonyms : Tyrosine Kinase Growth Factor Receptor; Transmembrane Receptor Protein Tyrosine Kinase; Receptor Protein-Tyrosine Kinase; Receptor-Tyrosine Kinase; RTK; EC 2.7.10.1; TRK; Tyrosine Receptor Kinase; EGF Receptor-Tyrosine Kinase Family; TKR; Tyrosine Kinase Receptor; Receptor-Type Protein-Tyrosine Kinase;

NCIt definition : A class of membrane receptors that contain protein tyrosine kinase activity. This enzymatic activity is integral to the function of the receptor as a signal transducer; the phosphorylation event alters the functional activity of its protein substrate.;

Details

Origin ID

C17660;

UMLS CUI

C0206364;

Biochemical function of gene products
- EphA Receptor Family [NCIt concept]
- Ephrin Receptor [NCIt concept]
- Interferon Alpha Receptor Complex [NCIt concept]
- Interferon Alpha/Beta Receptor 1 [NCIt concept]
- Interferon Alpha/Beta Receptor 2 [NCIt concept]
- Platelet-Derived Growth Factor Receptor [NCIt concept]
- Vascular Endothelial Growth Factor Receptor [NCIt concept]
Currated CISMeF NLP mapping
- receptor Protein-Tyrosine kinases [MeSH Descriptor]
- receptor Protein-Tyrosine kinases [MeSH concept]
False automatic mappings
- Total knee joint prosthesis (physical object) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- receptor Protein-Tyrosine kinases [MeSH concept]
- receptor Protein-Tyrosine kinases [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Bosutinib [NCIt concept]
- Imatinib Mesylate [NCIt concept]
- Lapatinib [NCIt concept]
- Nilotinib [NCIt concept]
- Nilotinib Hydrochloride Anhydrous [NCIt concept]
- Nilotinib Hydrochloride Monohydrate [NCIt concept]
- Pegdinetanib [NCIt concept]
- Sunitinib [NCIt concept]
- Sunitinib Malate [NCIt concept]
- Tesevatinib [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Ligand Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]

Keyword's position in hierarchy(ies) :

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