FLT3/FGFR Dual Kinase Inhibitor MAX-40279

Preferred Label : FLT3/FGFR Dual Kinase Inhibitor MAX-40279;

NCIt synonyms : FLT3/FGFR Kinase Inhibitor MAX-40279;

NCIt related terms : MAX-40279;

NCIt definition : An orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) and FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2), with potential antineoplastic activity. Upon oral administration of FLT3/FGFR dual kinase inhibitor MAX-40279, this agent binds to and inhibits both FGFR and FLT3, including FLT3 mutant forms, which results in the inhibition of FGFR/FLT3-mediated signal transduction pathways. This inhibits proliferation in FGFR/FLT3-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases, is upregulated in many tumor cell types. FLT3, a class III receptor tyrosine kinase (RTK), is overexpressed or mutated in most B-lineage neoplasms and in acute myeloid leukemias. They both play key roles in cellular proliferation and survival.;

UNII : DL772G3NN7;

CAS number : 2070931-57-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2070931-57-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : Max 4; MAX-40279-01; MAX 40279; MAX-40279;

NCI Metathesaurus CUI : CL1412016;

Details

Origin ID

C174517;

UMLS CUI

C5139859;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Fibroblast Growth Factor Receptor Family [NCIt concept]

Keyword's position in hierarchy(ies) :

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