Preferred Label : Nefextinib;
NCIt synonyms : FLT3/FGFR Kinase Inhibitor MAX-40279; FLT3/FGFR Dual Kinase Inhibitor MAX-40279;
NCIt definition : An orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) and
FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2), with potential antineoplastic
activity. Upon oral administration, nefextinib binds to and inhibits both FGFR and
FLT3, including FLT3 mutant forms, which results in the inhibition of FGFR/FLT3-mediated
signal transduction pathways. This inhibits proliferation in FGFR/FLT3-overexpressing
tumor cells. FGFR, a family of receptor tyrosine kinases, is upregulated in many tumor
cell types. FLT3, a class III receptor tyrosine kinase (RTK), is overexpressed or
mutated in most B-lineage neoplasms and in acute myeloid leukemias. They both play
key roles in cellular proliferation and survival.;
UNII : DL772G3NN7;
CAS number : 2070931-57-4;
Molecule name : Max 4; MAX-40279-01; MAX 40279; MAX-40279;
NCI Metathesaurus CUI : CL1412016;
Origin ID : C174517;
UMLS CUI : C5139859;
Semantic type(s)
- concept_is_in_subset
- has_target
