Preferred Label : FGFR/VEGFR/PDGFR/FLT3/SRC Inhibitor XL999;
NCIt synonyms : SSKI XL999; Spectrum Selective Kinase Inhibitor XL999;
NCIt related terms : XL-999;
NCIt definition : A small molecule inhibitor of numerous tyrosine kinases (TKs) including fibroblast
growth factor receptor (FGFR), vascular endothelial growth factor receptor (VEGFR),
platelet-derived growth factor receptor (PDGFR), FMS-related tyrosine kinase 3 (FLT3),
and SRC, with potential antineoplastic activity. Upon administration, XL999 binds
to and inhibits the activity of these TKs, thereby preventing both the activation
of downstream signaling pathways and the proliferation of tumor cells overexpressing
these TKs. FGFR, VEGFR, PDGFR, FLT-3, and SRC are upregulated in a variety of cancer
cell types and play key roles in tumor cell proliferation, angiogenesis, and metastasis.;
UNII : 6I7PLF6N8L;
CAS number : 705946-27-6;
Molecule name : XL-999;
Origin ID : C116894;
UMLS CUI : C1541529;
Semantic type(s)
- concept_is_in_subset
- has_target
