Aurora Kinase Inhibitor SNS-314

Preferred Label : Aurora Kinase Inhibitor SNS-314;

NCIt related terms : SNS-314;

NCIt definition : A synthetic small molecule Aurora kinase (AK) inhibitor with potential antineoplastic activity. Aurora kinase inhibitor SNS-314 selectively binds to and inhibits AKs A and B, which may result in the inhibition of cellular division and proliferation in tumor cells that overexpress AKs. AKs are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis.;

UNII : 802IFJ0Z8X;

CAS number : 1057249-41-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1057249-41-8 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : SNS-314;

Details

Origin ID

C70655;

UMLS CUI

C2346877;

CISMeF manual mappings
- SNS 314 [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- SNS 314 [MeSH concept]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- SNS 314 [MeSH Supplementary Concept]
- SNS 314 [MeSH concept]
chemical_or_drug_affects_gene_product
- Aurora Kinase A [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Enzyme Inhibition [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
- Signal Transduction Inhibition [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Aurora Kinase A [NCIt concept]

Keyword's position in hierarchy(ies) :

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