Multikinase Inhibitor AT9283

Preferred Label : Multikinase Inhibitor AT9283;

NCIt related terms : AT-9283; Aurora kinase inhibitor AT9283; AT9283;

NCIt definition : A small synthetic molecule and aurora kinase (AK) inhibitor with potential antineoplastic activity. AT9283 selectively binds to and inhibits AKs A and B, which are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis. Inhibition of these kinases results in an inhibition of cellular division and proliferation in tumor cells that overexpress AKs.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of some types of cancer. It blocks enzymes (Aurora kinases) involved in cell division and may kill cancer cells. AT9283 is a type of serine/threonine protein kinase inhibitor.;

UNII : XAV9KYN9WL;

CAS number : 896466-04-9;

Molecule name : AT9283;

Codes from synonyms : CDR0000538636; CDR0000572147;

Details

Origin ID

C66947;

UMLS CUI

C2987633;

See also inter- (CISMeF)
- AT 9283 [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_gene_product
- Aurora Kinase A [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Enzyme Inhibition [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
- Signal Transduction Inhibition [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Aurora Kinase A [NCIt concept]

Keyword's position in hierarchy(ies) :

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