NCIt definition : A water-soluble, synthetic small molecule with potential antineoplastic activity.
Cenisertib selectively binds to and inhibits aurora kinases (AKs), a family of serine-threonine
kinases which are important regulators of cell division and proliferation, and which
are overexpressed in certain types of cancer. Inhibition of aurora kinases inhibits
cell division and proliferation and induces apoptosis in tumor cells overexpressing
AKs.;
UNII : 5277GPA358;
InChIKey : KSOVGRCOLZZTPF-QMKUDKLTSA-N;
CAS number : 871357-89-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 871357-89-0
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Semantic type(s)