NCIt definition : An orally bioavailable small molecule multi-kinase inhibitor with antineoplastic activity.
Aurora kinase/VEGFR 2 inhibitor CYC116 inhibits Aurora kinases A and B and vascular
endothelial growth factor receptor 2 (VEGFR2), resulting in disruption of the cell
cycle, rapid cell death, and the inhibition of angiogenesis. Aurora kinases are serine/threonine
protein kinases that are only expressed in actively dividing cells and are critical
in division or mitosis. VEGFR2 is a receptor tyrosine kinase that appears to account
for most of the mitogenic and chemotactic effects of vascular endothelial growth factor
(VEGF) on adult endothelial cells.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of some types of cancer. It
blocks certain enzymes involved in cell division and may kill cancer cells. It may
also prevent the growth of new blood vessels that tumors need to grow. It is a type
of protein kinase inhibitor and a type of antiangiogenesis agent.;