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Aurora A Kinase/Tyrosine Kinase Inhibitor ENMD-2076 - CISMeF
Aurora A Kinase/Tyrosine Kinase Inhibitor ENMD-2076NCIt concept
Preferred Label : Aurora A Kinase/Tyrosine Kinase Inhibitor ENMD-2076;
NCIt synonyms : Aurora A Kinase Tyrosine Kinase Inhibitor ENMD-2076;
NCIt related terms : ENMD-2076;
NCIt definition : An orally bioavailable synthetic small molecule with potential antiangiogenic and
antineoplastic activities. Aurora A kinase/tyrosine kinase inhibitor ENMD-2076 selectively
binds to and inhibits non-specified tyrosine kinases and Aurora kinases (AKs). The
inhibition of AKs may result in the inhibition of cell division and proliferation
and may induce apoptosis in tumor cells that overexpress AKs; antiangiogenic activity
is related to the inhibition of angiogenic tyrosine kinases. AKs are serine-threonine
kinases that play an essential role in mitotic checkpoint control during mitosis and
are important regulators of cell division and proliferation.;
UNII : KXQ762CQTH;
CAS number : 1453868-32-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1453868-32-0
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Semantic type(s)