Aurora A Kinase/Tyrosine Kinase Inhibitor ENMD-2076

Preferred Label : Aurora A Kinase/Tyrosine Kinase Inhibitor ENMD-2076;

NCIt synonyms : Aurora A Kinase Tyrosine Kinase Inhibitor ENMD-2076;

NCIt related terms : ENMD-2076;

NCIt definition : An orally bioavailable synthetic small molecule with potential antiangiogenic and antineoplastic activities. Aurora A kinase/tyrosine kinase inhibitor ENMD-2076 selectively binds to and inhibits non-specified tyrosine kinases and Aurora kinases (AKs). The inhibition of AKs may result in the inhibition of cell division and proliferation and may induce apoptosis in tumor cells that overexpress AKs; antiangiogenic activity is related to the inhibition of angiogenic tyrosine kinases. AKs are serine-threonine kinases that play an essential role in mitotic checkpoint control during mitosis and are important regulators of cell division and proliferation.;

UNII : KXQ762CQTH;

CAS number : 1453868-32-0;

Molecule name : ENMD-2076;

Details

Origin ID

C78190;

UMLS CUI

C2698202;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_gene_product
- Aurora Kinase A [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Aurora Kinase A [NCIt concept]

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