Preferred Label : Aurora A Kinase Inhibitor JAB-2485;
NCIt synonyms : Aurora A Inhibitor JAB-2485;
NCIt definition : An orally bioavailable small molecule inhibitor of the serine/threonine protein kinase
Aurora A, with potential antimitotic and antineoplastic activities. Upon oral administration,
Aurora A kinase inhibitor JAB-2485 binds to and inhibits Aurora A kinase, which may
result in disruption of the assembly of the mitotic spindle apparatus, disruption
of chromosome segregation, inhibition of cell division and the induction of apoptosis
in cells overexpressing Aurora A kinase. Aurora A kinase localizes to the spindle
poles and to spindle microtubules during mitosis; it plays an essential role in the
regulation of spindle assembly. Aurora kinase A is overexpressed in a wide variety
of cancers.;
Semantic type(s)