" /> Danusertib - CISMeF





Preferred Label : Danusertib;

NCIt synonyms : Benzamide, 4-(4-methyl-1-piperazinyl)-N-(1,4,5,6-tetrahydro-5-((2R)- methoxyphenylacetyl)pyrrolo(3,4-c)pyrazol-3-yl)-;

NCIt related terms : PHA-739358;

NCIt definition : A small-molecule 3-aminopyrazole derivative with potential antineoplastic activity. Danusertib binds to and inhibits the Aurora kinases, which may result in cell growth arrest and apoptosis in tumor cells in which Aurora kinases are overexpressed. This agent may preferentially bind to and inhibit Aurora B kinase. Aurora kinases, a family of serine-threonine kinases, are important regulators of cellular proliferation and division.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of chronic myelogenous leukemia. PHA-739358 may stop tumor growth by blocking certain enzymes needed for cancer cells to divide and causing them to die. It is a type of kinase inhibitor.;

UNII : M3X659D0FY;

InChIKey : XKFTZKGMDDZMJI-HSZRJFAPSA-N;

CAS number : 827318-97-8;

Molecule name : PHA-739358;

Chemical formula : C26H30N6O3;

Codes from synonyms : CDR0000514434;

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27/05/2025


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