" /> Aurora A Kinase Inhibitor MK5108 - CISMeF





Preferred Label : Aurora A Kinase Inhibitor MK5108;

NCIt related terms : MK-5108;

NCIt definition : An orally bioavailable, highly selective small molecule inhibitor of the serine/threonine protein kinase Aurora A, with potential antimitotic and antineoplastic activity. Aurora A kinase inhibitor MK5108 binds to and inhibits Aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and eventually inhibition of cell division, proliferation and an induction of apoptosis in cells overexpressing Aurora A kinase. Aurora A kinase localizes to the spindle poles and to spindle microtubules during mitosis, and is thought to regulate spindle assembly. Aurora kinases are overexpressed in a wide variety of cancers.;

UNII : H8J407531S;

InChIKey : LCVIRAZGMYMNNT-VVONHTQRSA-N;

CAS number : 1010085-13-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1010085-13-8 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : MK-5108; MK 5108;

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12/05/2024


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