Tozasertib Lactate

Preferred Label : Tozasertib Lactate;

NCIt synonyms : Aurora Kinase Inhibitor MK-0457; Propanoic acid, 2-hydroxy-, (2S)-, compd. with N-(4-((4-(4-methyl-1-piperazinyl)-6-((5-methyl-1H-pyrazol-3-yl)amino)-2-pyrimidinyl)thio)phenyl)cyclopropanecarboxamide;

NCIt definition : The lactate salt of tozasertib, a synthetic, small-molecule Aurora kinase inhibitor with potential antitumor activity. Tozasertib binds to and inhibits Aurora kinases (AKs), thereby inducing apoptosis in tumor cells in which AKs are overexpressed. AKs, a family of serine-threonine kinases, are essential for mitotic progression, spindle formation, centrosome maturation, chromosomal segregation, and cytokinesis.;

UNII : CN8EF9N084;

InChIKey : MHFUWOIXNMZFIW-WNQIDUERSA-N;

CAS number : 899827-04-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 899827-04-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : L-001281814; VX-680; MK-0457;

Chemical formula : C23H28N8OS.C3H6O3;

Details

Origin ID

C61319;

UMLS CUI

C1831830;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_gene_product
- Aurora Kinase A [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Tozasertib [NCIt concept]
has_target
- Aurora Kinase A [NCIt concept]
- Aurora Kinase B [NCIt concept]
- Aurora Kinase C [NCIt concept]
is_salt_form_of
- Tozasertib [NCIt concept]

Keyword's position in hierarchy(ies) :

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