NCIt definition : An orally bioavailable Polo-like kinase 1 (Plk1) inhibitor with potential antineoplastic
activity. Polo-like kinase 1 inhibitor MK1496 selectively inhibits Plk1, inducing
selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing
reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1,
named after the polo gene of Drosophila melanogaster, is a serine/threonine protein
kinase involved in regulating mitotic spindle function in a non-ATP competitive manner.;