" /> Polo-like Kinase 1 Inhibitor MK1496 - CISMeF





Preferred Label : Polo-like Kinase 1 Inhibitor MK1496;

NCIt synonyms : PLK1 Inhibitor MK1496;

NCIt definition : An orally bioavailable Polo-like kinase 1 (Plk1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor MK1496 selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner.;

Molecule name : MK1496;

NCI Metathesaurus CUI : CL408660;

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30/07/2025


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