Polo-like Kinase 1 Inhibitor MK1496

Preferred Label : Polo-like Kinase 1 Inhibitor MK1496;

NCIt synonyms : PLK1 Inhibitor MK1496;

NCIt definition : An orally bioavailable Polo-like kinase 1 (Plk1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor MK1496 selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner.;

Molecule name : MK1496;

NCI Metathesaurus CUI : CL408660;

Détails

Origin ID

C82389;

UMLS CUI

C2826142;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_gene_product
- Serine/Threonine-Protein Kinase PLK1 [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Enzyme Inhibition [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
- Signal Transduction Inhibition [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Aurora Kinase A [NCIt concept]

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