PLK1 Inhibitor TAK-960

Preferred Label : PLK1 Inhibitor TAK-960;

NCIt synonyms : Polo-like Kinase 1 Inhibitor TAK-960;

NCIt related terms : TAK-960;

NCIt definition : An orally available, Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor TAK-960 selectively inhibits PLK1, inducing selective G2/M cell-cycle arrest followed by apoptosis in a variety of tumor cells while causing reversible cell-cycle arrest at the G1 and G2 stages without apoptosis in normal cells. PLK1 inhibition may result in the inhibition of proliferation in PLK1-overexpressed tumor cells. PLK1, named after the polo gene of Drosophila melanogaster, is a serine/threonine kinase crucial in the regulation of mitosis.;

UNII : 3831VFM1ZB;

CAS number : 1137868-52-0;

Molecule name : TAK-960;

Details

Origin ID

C92587;

UMLS CUI

C2985196;

Currated CISMeF NLP mapping
- TAK-960 [MeSH concept]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- TAK-960 [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Serine/Threonine-Protein Kinase PLK1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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