" /> Volasertib - CISMeF





Preferred Label : Volasertib;

NCIt synonyms : Polo-like Kinase 1 Inhibitor BI 6727; Benzamide, N-(Trans-4-(4-(Cyclopropylmethyl)-1-Piperazinyl)Cyclohexyl)-4-(((7r)-7-Ethyl-5,6,7,8-Tetrahydro-5-Methyl-8-(1-Methylethyl)-6-Oxo-2-Pteridinyl)Amino)-3-Methoxy-;

NCIt definition : A dihydropteridinone Polo-like kinase 1 (Plk1) inhibitor with potential antineoplastic activity. Volasertib selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner.;

UNII : 6EM57086EA;

InChIKey : SXNJFOWDRLKDSF-STROYTFGSA-N;

CAS number : 755038-65-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 755038-65-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : BI 6727; BI-6727;

Chemical formula : C34H50N8O3;

Codes from synonyms : 542;

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15/05/2024


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