NCIt definition : The trihydrochloride form of volasertib, a dihydropteridinone Polo-like kinase 1 (Plk1)
inhibitor, with potential antineoplastic activity. Volasertib selectively inhibits
Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells
while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal
cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine
protein kinase involved in regulating mitotic spindle function in a non-ATP competitive
manner.;
Semantic type(s)