Preferred Label : Plogosertib;
NCIt synonyms : PLK-1 Inhibitor CYC140; Polo-like Kinase 1 Inhibitor CYC140; PLK1 Inhibitor CYC140;
NCIt definition : A competitive inhibitor for adenosine triphosphate (ATP) binding to polo-like kinase
1 (PLK1; PLK-1; STPK13), with potential antineoplastic activity. Upon administration,
plogosertib selectively targets, binds to and inhibits PLK1, which disrupts mitosis
and induces selective G2/M cell-cycle arrest followed by apoptosis in PLK1-overexpressing
tumor cells. PLK1, named after the polo gene of Drosophila melanogaster, is a serine/threonine
kinase that is crucial for the regulation of mitosis, and plays a key role in tumor
cell proliferation, transformation and invasion. PLK1 expression is upregulated in
a variety of tumor cell types and high expression is associated with increased aggressiveness
and poor prognosis.;
UNII : IW5U2LC9XI;
CAS number : 1137212-79-3;
Molecule name : CYC-140; CYC 140;
NCI Metathesaurus CUI : CL970820;
Origin ID : C162375;
UMLS CUI : C5783380;
Semantic type(s)
- concept_is_in_subset
- has_target
