Progesterone-Mediated Oocyte Maturation Pathway

Preferred Label : Progesterone-Mediated Oocyte Maturation Pathway;

NCIt related terms : Progesterone-mediated oocyte maturation;

Alternative definition : KEGG: Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.;

KEGG ID : hsa04914;

Details

Origin ID

C91492;

UMLS CUI

C2984303;

Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- Adenylate Cyclase Type 9 [NCIt concept]
- Cytoplasmic Polyadenylation Element-Binding Protein 3 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- Fizzy-Related Protein Homolog [NCIt concept]
- G2/Mitotic-Specific Cyclin-B3 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(i) Subunit Alpha-1 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(i) Subunit Alpha-2 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(k) Subunit Alpha [NCIt concept]
- Heat Shock Protein HSP 90-Alpha [NCIt concept]
- Heat Shock Protein HSP 90-Beta [NCIt concept]
- Insulin-Like Growth Factor 1 Receptor [NCIt concept]
- Insulin-Like Growth Factor I [NCIt concept]
- Kinesin-Like Protein KIF22 [NCIt concept]
- Membrane-Associated Tyrosine- and Threonine-Specific Cdc2-Inhibitory Kinase [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 10 [NCIt concept]
- Mitogen-Activated Protein Kinase 11 [NCIt concept]
- Mitogen-Activated Protein Kinase 12 [NCIt concept]
- Mitogen-Activated Protein Kinase 13 [NCIt concept]
- Mitogen-Activated Protein Kinase 14 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Mitogen-Activated Protein Kinase 8 [NCIt concept]
- Mitogen-Activated Protein Kinase 9 [NCIt concept]
- Mitotic Checkpoint Serine/Threonine-Protein Kinase BUB1 [NCIt concept]
- Mitotic Spindle Assembly Checkpoint Protein MAD2A [NCIt concept]
- Mitotic Spindle Assembly Checkpoint Protein MAD2B [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Beta [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Gamma [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform [NCIt concept]
- Phosphoinositide 3-Kinase Regulatory Subunit 5 [NCIt concept]
- Progesterone Receptor [NCIt concept]
- Proto-Oncogene Serine/Threonine-Protein Kinase mos [NCIt concept]
- RAC-Alpha Serine/Threonine Kinase [NCIt concept]
- RAC-Beta Serine/Threonine Kinase [NCIt concept]
- RAC-Gamma Serine/Threonine Kinase [NCIt concept]
- Ribosomal Protein S6 Kinase Alpha-1 [NCIt concept]
- Ribosomal Protein S6 Kinase Alpha-2 [NCIt concept]
- Ribosomal Protein S6 Kinase Alpha-3 [NCIt concept]
- Ribosomal Protein S6 Kinase Alpha-6 [NCIt concept]
- Serine/Threonine-Protein Kinase A-Raf [NCIt concept]
- Serine/Threonine-Protein Kinase B-Raf [NCIt concept]
- Serine/Threonine-Protein Kinase PLK1 [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Alpha [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Beta [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Gamma [NCIt concept]
pathway_has_gene_element
- ADCY9 wt Allele [NCIt concept]
- AKT1 wt Allele [NCIt concept]
- AKT2 wt Allele [NCIt concept]
- AKT3 wt Allele [NCIt concept]
- ARAF wt Allele [NCIt concept]
- BRAF wt Allele [NCIt concept]
- BUB1 wt Allele [NCIt concept]
- CCNB3 wt Allele [NCIt concept]
- CPEB3 wt Allele [NCIt concept]
- FZR1 wt Allele [NCIt concept]
- GNAI1 wt Allele [NCIt concept]
- GNAI2 wt Allele [NCIt concept]
- GNAI3 wt Allele [NCIt concept]
- HSP90AA1 wt Allele [NCIt concept]
- HSP90AB1 wt Allele [NCIt concept]
- IGF1 wt Allele [NCIt concept]
- IGF1R wt Allele [NCIt concept]
- KIF22 wt Allele [NCIt concept]
- MAD2L1 wt Allele [NCIt concept]
- MAD2L2 wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK10 wt Allele [NCIt concept]
- MAPK11 wt Allele [NCIt concept]
- MAPK12 wt Allele [NCIt concept]
- MAPK13 wt Allele [NCIt concept]
- MAPK14 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MAPK8 wt Allele [NCIt concept]
- MAPK9 wt Allele [NCIt concept]
- MOS wt Allele [NCIt concept]
- PGR wt Allele [NCIt concept]
- PIK3CA wt Allele [NCIt concept]
- PIK3CB wt Allele [NCIt concept]
- PIK3CD wt Allele [NCIt concept]
- PIK3CG wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- PIK3R2 wt Allele [NCIt concept]
- PIK3R3 wt Allele [NCIt concept]
- PIK3R5 wt Allele [NCIt concept]
- PKMYT1 wt Allele [NCIt concept]
- PLK1 wt Allele [NCIt concept]
- PRKACA wt Allele [NCIt concept]
- PRKACB wt Allele [NCIt concept]
- PRKACG wt Allele [NCIt concept]
- RPS6KA1 wt Allele [NCIt concept]
- RPS6KA2 wt Allele [NCIt concept]
- RPS6KA3 wt Allele [NCIt concept]
- RPS6KA6 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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