Preferred Label : Polo-Box Domain;
NCIt definition : Members of the polo subfamily of protein kinases appear to play pivotal roles in cell
division and proliferation. These include mammalian Plk, Snk, and Fnk/Prk, Xenopus
laevis Plx1, Drosophila melanogaster polo, Schizosaccharomyces pombe Plo1, and Saccharomyces
cerevisiae Cdc5. The polo family members are characterized by the presence of a distinct
region of homology in the C-terminal non-catalytic domain, termed the polo-box, which
is essential for subcellular localization and mitotic functions of the polo kinases.
Regulation of polo kinases may be crucial in the control of cell division.;
Origin ID : C25986;
UMLS CUI : C1514191;
Semantic type(s)
- is_structural_domain_or_motif_of_gene_product
