Serine/Threonine-Protein Kinase PLK4

Preferred Label : Serine/Threonine-Protein Kinase PLK4;

NCIt synonyms : Serine/Threonine Kinase 18; Serine/Threonine Protein Kinase 18; Serine/Threonine Protein Kinase SAK; Polo-Like Kinase 4; PLK-4; EC 2.7.11.21; Serine/Threonine-Protein Kinase Sak; Serine/Threonine-Protein Kinase 18;

NCIt definition : Serine/threonine-protein kinase PLK4 (970 aa, 109 kDa) is encoded by the human PLK4 gene. This protein plays a role in the duplication of centrioles during the cell cycle.;

NCI Metathesaurus CUI : CL480576;

Details

Origin ID

C119603;

UMLS CUI

C1452494;

Automatic exact mappings (from CISMeF team)
- Polo-like kinase 4 [OMIM gene]
- polo like kinase 4 [ORDO Gene]
OMIM relation
- Polo-like kinase 4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- PLK4 protein, human [MeSH Supplementary Concept]
- PLK4 protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- PLK4 Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Centriole [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Polo-Box Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- PLK2 and PLK4 Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- G2 to M Transition Process [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Ocifisertib [NCIt concept]
- Ocifisertib Fumarate [NCIt concept]
- PLK4 Inhibitor RP-1664 [NCIt concept]

Keyword's position in hierarchy(ies) :

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