NCIt definition : An orally available fumarate salt form of CFI-400945, a polo-like kinase 4 (PLK4)
inhibitor with potential antineoplastic activity. Upon oral administration, polo-like
kinase 4 inhibitor CFI-400945 selectively inhibits PLK4, which results in the disruption
of mitosis and the induction of apoptosis. PLK4 inhibition also prevents cell division
and inhibits proliferation of PLK4-overexpressing tumor cells. PLK4, a member of the
polo family of serine/threonine kinases overexpressed in a variety of cancer cell
types, plays a crucial role in the regulation of centriole duplication during the
cell cycle.;
UNII : 09OB3E5QTD;
CAS number : 1616420-30-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1616420-30-4
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Semantic type(s)