Ocifisertib - CISMeF

Preferred Label : Ocifisertib;

NCIt synonyms : PLK4 Inhibitor CFI-400945; CFI-400945 Free Base;

NCIt definition : A polo-like kinase 4 (PLK4) inhibitor with potential antineoplastic activity. Upon administration, ocifisertib selectively inhibits PLK4, which results in the disruption of mitosis and the induction of apoptosis. PLK4 inhibition also prevents cell division and inhibits proliferation of PLK4-overexpressing tumor cells. PLK4, a member of the polo family of serine/threonine kinases overexpressed in a variety of cancer cell types, plays a crucial role in the regulation of centriole duplication during the cell cycle.;

UNII : TL1UD860AA;

CAS number : 1338806-73-7;

NCI Metathesaurus CUI : CL1773476;

Details

Origin ID

C185146;

UMLS CUI

C5706863;

Automatic exact mappings (from CISMeF team)
- CFI-400945 [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Ocifisertib Fumarate [NCIt concept]
has_target
- Serine/Threonine-Protein Kinase PLK4 [NCIt concept]
is_free_acid_or_base_form_of
- Ocifisertib Fumarate [NCIt concept]

Keyword's position in hierarchy(ies) :

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