NCIt definition : A polo-like kinase 4 (PLK4) inhibitor with potential antineoplastic activity. Upon
administration, ocifisertib selectively inhibits PLK4, which results in the disruption
of mitosis and the induction of apoptosis. PLK4 inhibition also prevents cell division
and inhibits proliferation of PLK4-overexpressing tumor cells. PLK4, a member of the
polo family of serine/threonine kinases overexpressed in a variety of cancer cell
types, plays a crucial role in the regulation of centriole duplication during the
cell cycle.;