Preferred Label : Lipid Encapsulated Anti-PLK1 siRNA TKM-PLK1;
NCIt synonyms : PLK1 SNALP;
NCIt definition : short interfering RNAs (siRNAs) directed against polo-like kinase 1 (PLK1, STPK13),
with potential antineoplastic activity. Upon administration of lipid-encapsulated
anti-PLK1 siRNA TKM-PLK1, siRNA binds to PLK1 mRNA, which results in the inhibition
of both the translation and expression of the PLK1 protein. Blockage of PLK1 expression
prevents proper tumor cell mitosis, causes cell cycle arrest and tumor cell apoptosis.
This inhibits the proliferation of PLK1-overexpressing tumor cells. PLK1, named after
the polo gene of Drosophila melanogaster, is a serine/threonine kinase crucial in
the regulation of mitosis; its expression is upregulated in a variety of tumor cell
types and plays a key role in tumor cell proliferation. The pegylated lipid bilayer
of SNALP provides stability and protects siRNA degradation; it facilitates uptake
into the cell and release from endosomes.;
Molecule name : TKM-PLK1; TKM-080301; PLK1424;
NCI Metathesaurus CUI : CL433763;
Origin ID : C116889;
UMLS CUI : C3896756;
Semantic type(s)
- concept_is_in_subset
- has_target
