Ribosomal Protein S6 Kinase Alpha-3

Preferred Label : Ribosomal Protein S6 Kinase Alpha-3;

NCIt synonyms : S6K-Alpha 3; MAPKAP Kinase 1b; 90 kDa Ribosomal Protein S6 Kinase 3; p90-RSK 3; EC 2.7.11.1; MAP Kinase-Activated Protein Kinase 1b; RPS6KA3; MAPKAPK1B; S6K-Alpha-3; Insulin-Stimulated Protein Kinase 1; ISPK-1; Ribosomal Protein S6 Kinase 2; RSK-2; p90RSK3; MAPKAPK-1b; Ribosomal Protein S6 Kinase A3; Mitogen-Activated Protein Kinase-Activated Protein Kinase 1b; pp90RSK2; MAPK-Activated Protein Kinase 1b;

NCIt definition : Ribosomal protein S6 kinase alpha-3 (740 aa, 84 kDa) is encoded by the human RPS6KA3 gene. This protein plays a role in the mitogenic and stress-induced phosphorylation of substrates, which regulates cell survival, cell proliferation, transcription and translation.;

Details

Origin ID

C181647;

UMLS CUI

C2002841;

Automatic exact mappings (from CISMeF team)
- Ribosomal protein s6 kinase a3 [OMIM gene]
- ribosomal protein S6 kinase A3 [ORDO Gene]
- ribosomal protein S6 kinase A3 [HGNC gene]
- ribosomal protein S6 kinase, 90kDa, polypeptide 3 [MeSH Supplementary Concept]
OMIM relation
- Ribosomal protein s6 kinase a3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- RPS6KA3 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- RPS6KA3 Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Coregulation Pathway for Androgen Receptor Activity [NCIt concept]
- Epidermal Growth Factor Receptor Downstream Signaling Pathway [NCIt concept]
- Long-Term Potentiation Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
- Oocyte Meiosis Pathway [NCIt concept]
- PDGFR-beta Signaling Pathway [NCIt concept]
- Progesterone-Mediated Oocyte Maturation Pathway [NCIt concept]
- mTOR Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Negative Regulation of Apoptosis [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Stress Response Signaling [NCIt concept]
is_target
- RSK1-4 Inhibitor PMD-026 [NCIt concept]

Keyword's position in hierarchy(ies) :

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