Insulin-Like Growth Factor I

Preferred Label : Insulin-Like Growth Factor I;

NCIt synonyms : Insulin-Like Growth Factor-I; IGF-I; Somatomedin C; IGF1; Somatomedin-C; IGF I; Mechano Growth Factor; Insulin-Like Growth Factor 1; Insulin-Like Growth Factor-1; IGF-1; MGF;

NCIt definition : Insulin-like growth factor I (195 aa, 22 kDa) is encoded by the human IGF1 gene. This protein may be involved in the regulation of glucose metabolism.;

NCIt note : Similar to insulin, the full length insulin-like growth factor I precursor protein is cleaved at positions 48 and 188 to release a 70 amino acid growth factor and a 77 amino acid E peptide. (UniProt); Elevated serum levels of insulin-like growth factor-1 (IGF-1) may identify premenopausal women who are likely to develop breast cancer before age 50. (Int J Cancer. 2000; 88: 828-832, via Medscape);

Details

Origin ID

C16743;

UMLS CUI

C3712803;

Currated CISMeF NLP mapping
- Insulin-Like growth factor I [MeSH concept]
- Insulin-Like growth factor-I [OBSOLETE LOINC component]
- Insulin-like growth factor-I [LOINC component]
- Somatomedin C [MedDRA LLT]
- Somatomedin C (substance) [SNOMED CT concept]
- insulin-like growth factor 1 [Artificial nutrition thesaurus concept]
- insulin-like growth factor I (24-41) [MeSH concept]
- insulin-like growth factor I (24-41) [MeSH Supplementary Concept]
- insulin-like growth factor I (57-70) [MeSH concept]
- insulin-like growth factor I (57-70) [MeSH Supplementary Concept]
- insulin-like growth factor i [MeSH Descriptor]
- somatomedin c [SNOMED Notion]
OMIM relation
- Insulin-like growth factor I [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- IGF1 protein, human [MeSH concept]
- IGF1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Growth Factor Gene [NCIt concept]
- IGF1 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Growth Factor [NCIt concept]
gene_product_is_element_in_pathway
- Adherens Junction Stabilization Pathway [NCIt concept]
- Aldosterone-Regulated Sodium Reabsorption Pathway [NCIt concept]
- BAD Regulation Pathway [NCIt concept]
- Ceramide Signaling Pathway PID [NCIt concept]
- Dilated Cardiomyopathy Pathway [NCIt concept]
- Erythrocyte Differentiation Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Food Intake and Energy Homeostasis Pathway [NCIt concept]
- Glioblastoma Multiforme Pathway [NCIt concept]
- Hypertrophic Cardiomyopathy Pathway [NCIt concept]
- IGF-1 Signaling Pathway [NCIt concept]
- IGF1 Pathway [NCIt concept]
- Integrin Angiogenesis Pathway [NCIt concept]
- Long-Term Depression Pathway [NCIt concept]
- Longevity Pathway [NCIt concept]
- Melanoma Pathway [NCIt concept]
- NFAT Pathway [NCIt concept]
- Oocyte Meiosis Pathway [NCIt concept]
- Plasma Membrane Estrogen Receptor Signaling Pathway [NCIt concept]
- Progesterone-Mediated Oocyte Maturation Pathway [NCIt concept]
- Prostate Cancer Pathway [NCIt concept]
- Skeletal Muscle Hypertrophy Pathway [NCIt concept]
- Skeletal Myogenesis Pathway [NCIt concept]
- mTOR Signaling Pathway KEGG [NCIt concept]
- p53 Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation Regulatory Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Receptor Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Stimulation of Cell Proliferation [NCIt concept]
is_target
- Dusigitumab [NCIt concept]
- Xentuzumab [NCIt concept]

Keyword's position in hierarchy(ies) :

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