Dusigitumab - CISMeF

Preferred Label : Dusigitumab;

NCIt synonyms : Anti-Insulin-Like Growth Factor 1/2 Monoclonal Antibody MEDI-573; Anti-IGF 1 2 Monoclonal Antibody MEDI-573; Immunoglobulin G2, Anti-(Human Insulin-like Growth Factor I/Insulin-like Growth Factor II); Human Monoclonal MEDI-573 gamma Heavy Chain (134-216')-Disulfide with Human Monoclonal MEDI-573 lambda Light Chain Dimer (222-222'':223-223'':226-226'':229-229'')-Tetrakisdisulfide;

NCIt definition : A humanized monoclonal antibody directed against insulin-like growth factors 1 and 2 (IGF-1/2) with potential antineoplastic activity. Dusigitumab inhibits IGF1- and IGF2-stimulated activation of membrane-bound IGF receptors and the subsequent triggering of proliferation and survival signaling pathways. This may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF1/2 ligands stimulate cell proliferation, enable oncogenic transformation, and suppress apoptosis; IGF1/2 signaling has been highly implicated in tumorigenesis and metastasis.;

UNII : 0Z70DT5PRX;

CAS number : 1204390-13-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1204390-13-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : MEDI-573;

Details

Origin ID

C82683;

UMLS CUI

C4519591;

Automatic exact mappings (from CISMeF team)
- dusigitumab [MeSH concept]
Currated CISMeF NLP mapping
- dusigitumab [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- dusigitumab [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Insulin-Like Growth Factor I [NCIt concept]
- Insulin-Like Growth Factor II [NCIt concept]

Keyword's position in hierarchy(ies) :

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