Insulin-Like Growth Factor II

Preferred Label : Insulin-Like Growth Factor II;

NCIt synonyms : IGF2; Somatomedin A; IGF-II; Somatomedin-A; IGF-2; Insulin-Like Growth Factor 2; Insulin-Like Growth Factor-2;

NCIt definition : Insulin-like growth factor II (180 aa, 20 kDa) is encoded by the human IGF2 gene. This protein plays a role in cellular growth, development, and mitogenesis.;

NCIt note : Similar to insulin, the full length insulin-like growth factor II precursor protein is cleaved at positions 24 or 25 and at positions 91 and 180 to release a 67 or 66 amino acid growth factor and an 89 amino acid E peptide. The E peptide can be further processed to release prepeptin. (UniProt);

Details

Origin ID

C16744;

UMLS CUI

C1569730;

Currated CISMeF NLP mapping
- somatomedin a [SNOMED Notion]
False automatic mappings
- Somatomedin A (substance) [SNOMED CT concept]
OMIM relation
- Insulin-like growth factor II [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- IGF2 protein, human [MeSH concept]
- IGF2 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Growth Factor Gene [NCIt concept]
- IGF2 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Growth Factor [NCIt concept]
gene_product_is_biomarker_type
- Biomarker [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation Regulatory Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Receptor Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Stimulation of Cell Proliferation [NCIt concept]
is_target
- Dusigitumab [NCIt concept]
- Xentuzumab [NCIt concept]

Keyword's position in hierarchy(ies) :

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