Aldosterone-Regulated Sodium Reabsorption Pathway

Preferred Label : Aldosterone-Regulated Sodium Reabsorption Pathway;

NCIt related terms : Aldosterone-regulated sodium reabsorption;

Alternative definition : KEGG: Sodium transport across the tight epithelia of Na reabsorbing tissues such as the distal part of the kidney nephron and colon is the major factor determining total-body Na levels, and thus, long-term blood pressure. Aldosterone plays a major role in sodium and potassium metabolism by binding to epithelial mineralocorticoid receptors (MR) in the renal collecting duct cells localized in the distal nephron, promoting sodium resorption and potassium excretion. Aldosterone enters a target cell and binds MR, which translocates into the nucleus and regulates gene transcription. Activation of MR leads to increased expression of Sgk-1, which phosphorylates Nedd4-2, an ubiquitin-ligase which targets ENAC to proteasomal degradation. Phosphorylated Nedd4-2 dissociates from ENAC, increasing its apical membrane abundance. Activation of MR also leads to increased expression of Na /K -ATPase, thus causing a net increase in sodium uptake from the renal filtrate. The specificity of MR for aldosterone is provided by 11beta-HSD2 by the rapid conversion of cortisol to cortisone in renal cortical collecting duct cells. Recently, besides genomic effects mediated by activated MR, rapid aldosterone actions that are independent of translation and transcription have been documented.;

KEGG ID : hsa04960;

Details

Origin ID

C91503;

UMLS CUI

C2984313;

Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- 11-Beta-Hydroxysteroid Dehydrogenase Type 2 [NCIt concept]
- 14-3-3 Protein Sigma [NCIt concept]
- 3-Phosphoinositide-Dependent Protein Kinase 1 [NCIt concept]
- Insulin Receptor [NCIt concept]
- Insulin-Like Growth Factor I [NCIt concept]
- Mineralocorticoid Receptor [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Beta [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Gamma [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform [NCIt concept]
- Phosphoinositide 3-Kinase Regulatory Subunit 5 [NCIt concept]
- Protein Kinase C Alpha Type [NCIt concept]
- Protein Kinase C Beta Type [NCIt concept]
- Serine/Threonine-Protein Kinase Sgk1 [NCIt concept]
- Sodium/Potassium-Transporting ATPase Subunit Alpha-1 [NCIt concept]
- Sodium/Potassium-Transporting ATPase Subunit Alpha-3 [NCIt concept]
- Sodium/Potassium-Transporting ATPase Subunit Beta-3 [NCIt concept]
pathway_has_gene_element
- ATP1A1 wt Allele [NCIt concept]
- ATP1A3 wt Allele [NCIt concept]
- ATP1B3 wt Allele [NCIt concept]
- HSD11B2 wt Allele [NCIt concept]
- IGF1 wt Allele [NCIt concept]
- INSR wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- NR3C2 wt Allele [NCIt concept]
- PDPK1 wt Allele [NCIt concept]
- PIK3CA wt Allele [NCIt concept]
- PIK3CB wt Allele [NCIt concept]
- PIK3CD wt Allele [NCIt concept]
- PIK3CG wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- PIK3R2 wt Allele [NCIt concept]
- PIK3R3 wt Allele [NCIt concept]
- PIK3R5 wt Allele [NCIt concept]
- PRKCA wt Allele [NCIt concept]
- PRKCB wt Allele [NCIt concept]
- SFN wt Allele [NCIt concept]
- SGK1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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