Preferred Label : Aldosterone-Regulated Sodium Reabsorption Pathway;
NCIt related terms : Aldosterone-regulated sodium reabsorption;
Alternative definition : KEGG: Sodium transport across the tight epithelia of Na reabsorbing tissues such
as the distal part of the kidney nephron and colon is the major factor determining
total-body Na levels, and thus, long-term blood pressure. Aldosterone plays a major
role in sodium and potassium metabolism by binding to epithelial mineralocorticoid
receptors (MR) in the renal collecting duct cells localized in the distal nephron,
promoting sodium resorption and potassium excretion. Aldosterone enters a target cell
and binds MR, which translocates into the nucleus and regulates gene transcription.
Activation of MR leads to increased expression of Sgk-1, which phosphorylates Nedd4-2,
an ubiquitin-ligase which targets ENAC to proteasomal degradation. Phosphorylated
Nedd4-2 dissociates from ENAC, increasing its apical membrane abundance. Activation
of MR also leads to increased expression of Na /K -ATPase, thus causing a net increase
in sodium uptake from the renal filtrate. The specificity of MR for aldosterone is
provided by 11beta-HSD2 by the rapid conversion of cortisol to cortisone in renal
cortical collecting duct cells. Recently, besides genomic effects mediated by activated
MR, rapid aldosterone actions that are independent of translation and transcription
have been documented.;
KEGG ID : hsa04960;
Origin ID : C91503;
UMLS CUI : C2984313;
Semantic type(s)
has_gene_product_element
pathway_has_gene_element