PRKCB wt Allele

Preferred Label : PRKCB wt Allele;

NCIt synonyms : PKC-beta; PKCB; MGC41878; PRKCB2; PRKCB1 wt Allele; Protein Kinase C, Beta-1 Gene; PRKCB1; Protein Kinase C, Beta 1 Gene; Protein Kinase C, Beta wt Allele;

NCIt definition : Human PRKCB1 wild-type allele is located in the vicinity of 16p11.2 and is approximately 384 kb in length. This allele, which encodes protein kinase C beta type protein, plays a role in the phosphorylation of many protein substrates in response to activation by calcium or the second messenger diacylglycerol. Certain allelic variants of the PRKCB1 gene are associated with susceptibility to diabetic nephropathy in individuals with either type I or type II diabetes mellitus.;

NCIt note : Overexpression of the PRKCB1 gene is associated with certain types of cancer such as acute lymphocytic leukemia and breast carcinomas.;

GenBank Accession Number : NM_002738;

Details

Origin ID

C51272;

UMLS CUI

C1706144;

Automatic exact mappings (from CISMeF team)
- Protein kinase C, beta [OMIM gene]
- protein kinase C activity [GO term]
- protein kinase C beta [MeSH Descriptor]
- protein kinase C beta [MeSH concept]
OMIM relation
- Protein kinase C, beta [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_has_abnormality
- PKCbeta1 Messenger RNA Overexpression [NCIt concept]
gene_in_chromosomal_location
- 16p11.2 [NCIt concept]
gene_is_element_in_pathway
- Aldosterone-Regulated Sodium Reabsorption Pathway [NCIt concept]
- Amoebiasis Pathway [NCIt concept]
- B Cell Receptor Signaling Pathway [NCIt concept]
- Bioactive Peptide Signaling Pathway [NCIt concept]
- Calcium-Mediated Signaling Pathway [NCIt concept]
- Chemokine Signaling Pathway [NCIt concept]
- Downstream Signaling Pathway in Naive CD8+ T Cells [NCIt concept]
- ERBB Family Signaling Pathway [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway BioCarta [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway KEGG [NCIt concept]
- Fc Gamma Receptor-Mediated Phagocytosis Pathway [NCIt concept]
- Fc-Epsilon Receptor I Signaling Pathway PID [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Gap Junction Assembly Pathway [NCIt concept]
- Gastric Acid Secretion Pathway [NCIt concept]
- Glioblastoma Multiforme Pathway [NCIt concept]
- Gonadotropin-Releasing Hormone Signaling Pathway [NCIt concept]
- Ion Channel and Phorbal Esters Signaling Pathway [NCIt concept]
- JNK Signaling in the CD4+ TCR Pathway [NCIt concept]
- Leishmaniasis Infection Pathway [NCIt concept]
- Leukocyte Transendothelial Migration Pathway [NCIt concept]
- Long-Term Depression Pathway [NCIt concept]
- Long-Term Potentiation Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- Melanogenesis Pathway [NCIt concept]
- Natural Killer Cell-Mediated Cytotoxicity Pathway [NCIt concept]
- Non-Small Cell Lung Cancer Pathway [NCIt concept]
- Phosphatidylinositol Signaling System Pathway [NCIt concept]
- Ras Signaling in the CD4+ TCR Pathway [NCIt concept]
- Salivary Secretion Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway BioCarta [NCIt concept]
- T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells [NCIt concept]
- T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells [NCIt concept]
- Tight Junction Assembly Pathway [NCIt concept]
- VEGF Signaling Pathway [NCIt concept]
- VEGFR1 Signaling Pathway [NCIt concept]
- VEGFR1 and VEGFR2 Signaling [NCIt concept]
- Vascular Smooth Muscle Contraction Pathway [NCIt concept]
- Vibrio cholerae Infection Pathway [NCIt concept]
- Wnt Signaling Pathway KEGG [NCIt concept]
- mTOR Signaling Pathway KEGG [NCIt concept]
gene_plays_role_in_process
- Calcium Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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