Gastric Acid Secretion Pathway

Preferred Label : Gastric Acid Secretion Pathway;

NCIt related terms : Gastric acid secretion;

Alternative definition : KEGG: Gastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections. The principal stimulants of acid secretion at the level of the parietal cell are histamine (paracrine), gastrin (hormonal), and acetylcholine (ACh; neurocrine). Stimulation of acid secretion typically involves an initial elevation of intracellular calcium and cAMP, followed by activation of protein kinase cascades, which trigger the translocation of the proton pump, H , K -ATPase, from cytoplasmic tubulovesicles to the apical plasma membrane and H secretion into the stomach lumen.;

KEGG ID : hsa04971;

Details

Origin ID

C91811;

UMLS CUI

C2984576;

Automatic exact mappings (from CISMeF team)
- Gastric acid secretion (observable entity) [SNOMED CT concept]
- gastric acid secretion [GO term]
Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-3 [NCIt concept]
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-4 [NCIt concept]
- Actin, Cytoplasmic 1 [NCIt concept]
- Adenylate Cyclase Type 9 [NCIt concept]
- Calcium/Calmodulin-Dependent Protein Kinase Type II Subunit Alpha [NCIt concept]
- Calmodulin [NCIt concept]
- Carbonic Anhydrase 2 [NCIt concept]
- Cystic Fibrosis Transmembrane Conductance Regulator [NCIt concept]
- Gastrin [NCIt concept]
- Gastrin/Cholecystokinin Type B Receptor [NCIt concept]
- Guanine Nucleotide-Binding Protein G(i) Subunit Alpha-1 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(i) Subunit Alpha-2 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(k) Subunit Alpha [NCIt concept]
- Histamine H2 Receptor [NCIt concept]
- Inositol 1,4,5-Trisphosphate Receptor Type 1 [NCIt concept]
- Inositol 1,4,5-Trisphosphate Receptor Type 2 [NCIt concept]
- Inward Rectifier Potassium Channel 2 [NCIt concept]
- Muscarinic Acetylcholine Receptor M3 [NCIt concept]
- Myosin Light Chain Kinase, Smooth Muscle [NCIt concept]
- Potassium Voltage-Gated Channel Subfamily KQT Member 1 [NCIt concept]
- Protein Kinase C Alpha Type [NCIt concept]
- Protein Kinase C Beta Type [NCIt concept]
- Sodium/Hydrogen Exchanger 1 [NCIt concept]
- Sodium/Potassium-Transporting ATPase Subunit Alpha-1 [NCIt concept]
- Sodium/Potassium-Transporting ATPase Subunit Alpha-3 [NCIt concept]
- Sodium/Potassium-Transporting ATPase Subunit Beta-3 [NCIt concept]
- Somatostatin [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Alpha [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Beta [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Gamma [NCIt concept]
pathway_has_gene_element
- ACTB wt Allele [NCIt concept]
- ADCY9 wt Allele [NCIt concept]
- ATP1A1 wt Allele [NCIt concept]
- ATP1A3 wt Allele [NCIt concept]
- ATP1B3 wt Allele [NCIt concept]
- CA2 wt Allele [NCIt concept]
- CALM1 wt Allele [NCIt concept]
- CAMK2A wt Allele [NCIt concept]
- CCKBR wt Allele [NCIt concept]
- CFTR wt Allele [NCIt concept]
- CHRM3 wt Allele [NCIt concept]
- GAST wt Allele [NCIt concept]
- GNAI1 wt Allele [NCIt concept]
- GNAI2 wt Allele [NCIt concept]
- GNAI3 wt Allele [NCIt concept]
- HRH2 wt Allele [NCIt concept]
- ITPR1 wt Allele [NCIt concept]
- ITPR2 wt Allele [NCIt concept]
- KCNJ2 wt Allele [NCIt concept]
- KCNQ1 wt Allele [NCIt concept]
- MYLK wt Allele [NCIt concept]
- PLCB3 wt Allele [NCIt concept]
- PLCB4 wt Allele [NCIt concept]
- PRKACA wt Allele [NCIt concept]
- PRKACB wt Allele [NCIt concept]
- PRKACG wt Allele [NCIt concept]
- PRKCA wt Allele [NCIt concept]
- PRKCB wt Allele [NCIt concept]
- SLC9A1 wt Allele [NCIt concept]
- SST wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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