Preferred Label : Gastrin/Cholecystokinin Type B Receptor;
NCIt synonyms : CCKBR; Cholecystokinin Type B Receptor; CCK-B Receptor; CCKRB; CCK-BR; Cholecystokinin B Receptor; GASR; Cholecystokinin-B Receptor; Cholecystokinin-2 Receptor; Gastrin Receptor; CCK2-R;
NCIt definition : Gastrin/cholecystokinin type B receptor (447 aa, 48 kDa) is encoded by the human
CCKBR gene. This protein is involved in peptide hormone binding and the regulation
of cell proliferation, feeding behavior, and sensory perception.;
NCIt note : Type B (gastrin) receptors of the cholecystokinin (CCK) family are found principally
in the CNS and the gastrointestinal tract. In the CNS, they regulate anxiety, arousal,
neuroleptic activity, and opiate-induced analgesia. Outside the CNS, they regulate
gastric acid secretion and may play a role in gastrointestinal motility and growth
of normal and neoplastic gastrointestinal tissue. Cholecystokinin B Receptor (CCKBR),
encoded by the CCKBR gene, is a G protein-coupled receptor for gastrin and cholecystokinin.
It activates a second messenger system involving phosphatidylinositol turnover and
intracellular calcium mobilization. CCKBR can selectively be blocked by nonpeptide
benzodiazepine-based antagonists. A single amino acid, valine-319, is critical in
determining the binding affinity for these nonpeptide antagonists. Variability in
the aliphatic side chain of the amino acid in position 319 confers antagonist specificity.
(NCI);
Origin ID : C21598;
UMLS CUI : C4082288;
Currated CISMeF NLP mapping
- OMIM relation
- Semantic type(s)
- concept_is_in_subset
- gene_encodes_gene_product
- gene_product_expressed_in_tissue
- gene_product_has_associated_anatomy
- gene_product_has_biochemical_function
- gene_product_has_chemical_classification
- gene_product_has_structural_domain_or_motif
- gene_product_is_element_in_pathway
- gene_product_plays_role_in_biological_process
- is_target
