Preferred Label : Netazepide;
NCIt synonyms : Cholecystokinin B Receptor Antagonist YF476; 1-((3R)-1-(3,3-Dimethyl-2-Oxobutyl)-2-Oxo-5-(Pyridin-2-yl)-2,3-Dihydro-1H-1,4-Benzodiazepin-3-yl)-3-(3-(Methylamino)Phenyl)Urea; Sograzepide;
NCIt definition : An orally active, benzodiazepine type, selective cholecystokinin B receptor (CCKBR;
CCK2R; gastrin receptor) antagonist with potential gastric acid reducing and antiproliferative
activity. Upon administration, netazepide, selectively binds to and blocks the CCKBR,
thereby preventing the binding of gastrin and cholecystokinin. This may prevent gastric
neuroendocrine enterochromaffin-like (ECL) cell-induced secretion of histamine, ultimately
preventing gastric acid secretion from adjacent parietal cells. In addition, YF476
may inhibit ECL cell proliferation and ECL-derived gastric carcinoids.;
UNII : HOU4I0G29C;
InChIKey : YDZYKNJZCVIKPP-VWLOTQADSA-N;
CAS number : 155488-25-8;
Molecule name : YF-476;
Chemical formula : C28H30N6O3;
Origin ID : C87692;
UMLS CUI : C3852776;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
