Gastrin - CISMeF

Preferred Label : Gastrin;

NCIt synonyms : (Prepro)Gastrin; Preprogastrin; GAST;

NCIt definition : Gastrin (101 aa, 11 kDa) is encoded by the human GAST gene. This protein plays a role in the modulation of gastric acid and pancreatic digestive enzyme secretion.;

Alternative definition : NCI-GLOSS: A hormone released from special cells in the lining of the stomach after eating. Gastrin causes the stomach to release an acid that helps digest food.;

NCIt note : The 101 amino acid prepro-form of gastrin can be cleaved between alanine residue 21 and serine 22 to generate the 80 amino acid progastrin. Intracellular gastrointestinal progastrin can be further cleaved to form the main circulating biologically active forms gastrin-34 (big gastrin) and gastrin-17 (little gastrin). Other processed forms are possible including gastrin-71, gastrin-52, gastrin-14, and gastrin-6. (UniProt);

Codes from synonyms : CDR0000458101;

Details

Origin ID

C94668;

UMLS CUI

C4520797;

Automatic exact mappings (from CISMeF team)
- Gastrin [OMIM gene]
- big big gastrin [SNOMED Notion]
- big gastrin [MeSH concept]
- big gastrin [MeSH Supplementary Concept]
- gastrin [HGNC gene]
- gastrin [Artificial nutrition thesaurus concept]
- gastrin [EMDN type]
- gastrin [medical devices type]
- gastrin i [SNOMED Notion]
- gastrin ii [SNOMED Notion]
Currated CISMeF NLP mapping
- Gastrin [FMA entity]
- Gastrin [LOINC component]
- Gastrin [MedDRA LLT]
- Gastrin (substance) [SNOMED CT concept]
- gastrin [MeSH concept]
- gastrin (4-17) [MeSH concept]
- gastrin (4-17) [MeSH Supplementary Concept]
- gastrin, nos [SNOMED Notion]
- gastrins [MeSH Descriptor]
- gastrins [MeSH concept]
False automatic mappings
- stomach [MeSH Descriptor]
OMIM relation
- Gastrin [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Hormone [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- GAST Gene [NCIt concept]
- Peptide Hormone Gene [NCIt concept]
gene_product_has_associated_anatomy
- Gastrointestinal Tract [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- Gastric Acid Secretion Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Digestion [NCIt concept]
- Gastric Acid Secretion Induction [NCIt concept]
- Intercellular Communication Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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