T Cell Receptor Signaling Pathway BioCarta

Preferred Label : T Cell Receptor Signaling Pathway BioCarta;

NCIt related terms : T Cell Receptor Signaling Pathway;

Alternative definition : BIOCARTA: The T Cell Receptor plays a key role in the immune system. The specificity of the receptor is governed by the binding site formed from the mature alpha and beta chains or gamma and delta chains in gamma/delta T Cells. It is the ability of this receptor to bind a complex of foreign peptide in the groove of an MHC molecule that leads to T cell activation. Upon activation the T cell can assist in activating other cells or carry out cytolytic attacks depending on the particular T cell type. The CD3 complex and CD4 (Th cells) or CD8 (Tc cells) work to transmit the activation signal to the T cell's transcriptional machinery upon engagement of the receptor. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_tcrPathway;

Details

Origin ID

C39246;

UMLS CUI

C1325934;

Automatic exact mappings (from CISMeF team)
- T cell receptor signaling pathway [GO term]
Semantic type(s)
- Molecular Function [UMLS semantic type]
UMLS correspondences (same concept)
- T cell receptor signaling pathway [GO term]
has_gene_product_element
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-1 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 4 [NCIt concept]
- ETS Domain-Containing Protein Elk-1 [NCIt concept]
- GTPase HRas [NCIt concept]
- Growth Factor Receptor-Bound Protein 2 [NCIt concept]
- HLA Class II Histocompatibility Antigen, DR Alpha Chain [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Mitogen-Activated Protein Kinase 8 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 1 [NCIt concept]
- NF-Kappa-B Inhibitor Alpha [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform [NCIt concept]
- Protein Kinase C Alpha Type [NCIt concept]
- Protein Kinase C Beta Type [NCIt concept]
- Proto-Oncogene Vav [NCIt concept]
- Proto-Oncogene c-Fos [NCIt concept]
- RAF Proto-Oncogene Serine/Threonine-Protein Kinase [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 1 [NCIt concept]
- SHC-Transforming Protein 1 [NCIt concept]
- STE20-Like Serine/Threonine-Protein Kinase [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Alpha Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Beta Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Gamma Isoform [NCIt concept]
- Son of Sevenless Homolog 1 [NCIt concept]
- T-Cell Surface Glycoprotein CD3 Delta Chain [NCIt concept]
- T-Cell Surface Glycoprotein CD3 Epsilon Chain [NCIt concept]
- T-Cell Surface Glycoprotein CD3 Gamma Chain [NCIt concept]
- T-Cell Surface Glycoprotein CD3 Zeta Chain [NCIt concept]
- Transcription Factor AP-1 [NCIt concept]
- Transcription Factor p65 [NCIt concept]
- Tyrosine-Protein Kinase Fyn [NCIt concept]
- Tyrosine-Protein Kinase Lck [NCIt concept]
- Tyrosine-Protein Kinase ZAP-70 [NCIt concept]
- Tyrosine-Protein Phosphatase Non-Receptor Type 7 [NCIt concept]
pathway_has_gene_element
- CD247 wt Allele [NCIt concept]
- CD3D wt Allele [NCIt concept]
- CD3E wt Allele [NCIt concept]
- CD3G wt Allele [NCIt concept]
- ELK1 wt Allele [NCIt concept]
- FOS wt Allele [NCIt concept]
- FYN wt Allele [NCIt concept]
- GRB2 wt Allele [NCIt concept]
- HLA-DRA wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- JUN wt Allele [NCIt concept]
- LCK wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAP2K2 wt Allele [NCIt concept]
- MAP2K4 wt Allele [NCIt concept]
- MAP3K1 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MAPK8 wt Allele [NCIt concept]
- NFKBIA wt Allele [NCIt concept]
- PIK3CA wt Allele [NCIt concept]
- PIK3CG wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- PLCG1 wt Allele [NCIt concept]
- PPP3CA wt Allele [NCIt concept]
- PPP3CB wt Allele [NCIt concept]
- PPP3CC wt Allele [NCIt concept]
- PRKCA wt Allele [NCIt concept]
- PRKCB wt Allele [NCIt concept]
- PTPN7 wt Allele [NCIt concept]
- RAC1 wt Allele [NCIt concept]
- RAF1 wt Allele [NCIt concept]
- RELA wt Allele [NCIt concept]
- SHC1 wt Allele [NCIt concept]
- SLK wt Allele [NCIt concept]
- SOS1 wt Allele [NCIt concept]
- VAV1 wt Allele [NCIt concept]
- ZAP70 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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