Tyrosine-Protein Phosphatase Non-Receptor Type 7

Preferred Label : Tyrosine-Protein Phosphatase Non-Receptor Type 7;

NCIt synonyms : Protein Tyrosine Phosphatase LC-PTP; Hematopoietic Protein Tyrosine Phosphatase; PTPN7; Hematopoietic Cell Protein-Tyrosine Phosphatase; EC 3.1.3.48; Protein Tyrosine Phosphatase, Non-Receptor Type 7; HEPTP; Non-Receptor Type 7 Protein Tyrosine Phosphatase;

NCIt definition : Tyrosine-protein phosphatase non-receptor type 7 (360 aa, 41 kDa) is encoded by the human PTPN7 gene. This protein is involved in the dephosphorylation of MAPK proteins.;

NCIt note : Tyrosine-protein phosphatase non-receptor type 7 preferentially dephosphorylates MAPK1.; PTPN7 appears to regulate T and B lymphocyte development and signal transduction.;

Details

Origin ID

C26345;

UMLS CUI

C1571063;

OMIM relation
- Protein-tyrosine phosphatase, nonreceptor-type, 7 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- PTPN7 protein, human [MeSH concept]
- PTPN7 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Esterase Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Non-Receptor Protein Tyrosine Phosphatase Gene [NCIt concept]
- PTPN7 Gene [NCIt concept]
- Phosphatase Family Gene [NCIt concept]
- Protein Phosphatase Gene [NCIt concept]
- Protein Tyrosine Phosphatase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Spleen [NCIt concept]
- Thymus Gland [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
gene_product_has_biochemical_function
- Hydrolase [NCIt concept]
gene_product_has_structural_domain_or_motif
- SH2 Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Downstream Signaling Pathway in Naive CD8+ T Cells [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- Phosphatidylinositol Signaling System Pathway [NCIt concept]
- Ras Signaling in the CD4+ TCR Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway BioCarta [NCIt concept]
gene_product_malfunction_associated_with_disease
- Non-Hodgkin Lymphoma [NCIt concept]
gene_product_plays_role_in_biological_process
- Dephosphorylation [NCIt concept]
- Hydrolysis [NCIt concept]
- Protein Dephosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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