Vibrio cholerae Infection Pathway

Preferred Label : Vibrio cholerae Infection Pathway;

NCIt synonyms : V. cholera Infection Pathway;

NCIt related terms : Vibrio cholerae infection;

Alternative definition : KEGG: Cholera toxin (CTX) is one of the main virulence factors of Vibrio cholerae. Once secreted, CTX B-chain (CTXB) binds to ganglioside GM1 on the surface of the host's cells. After binding takes place, the entire CTX complex is carried from plasma membrane (PM) to endoplasmic reticulum (ER). In the ER, the A-chain (CTXA) is recognized by protein disulfide isomerase (PDI), unfolded, and delivered to the membrane where the membrane-associated ER-oxidase, Ero1, oxidizes PDI to release the CTXA into the protein-conducting channel, Sec61. CTXA is then retro-translocated to the cytosol and induces water and electrolyte secretion by increasing cAMP levels via adenylate cyclase (AC) to exert toxicity.;

KEGG ID : hsa05110;

Details

Origin ID

C91464;

UMLS CUI

C2984276;

Automatic exact mappings (from CISMeF team)
- Cholera (disorder) [SNOMED CT concept]
- cholera [MeSH Descriptor]
Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-1 [NCIt concept]
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-2 [NCIt concept]
- ADP-Ribosylation Factor 1 [NCIt concept]
- Actin, Cytoplasmic 1 [NCIt concept]
- Actin, Cytoplasmic 2 [NCIt concept]
- Adenylate Cyclase Type 9 [NCIt concept]
- Cystic Fibrosis Transmembrane Conductance Regulator [NCIt concept]
- ERO1-Like Protein Alpha [NCIt concept]
- Mucin-2 [NCIt concept]
- Protein Kinase C Alpha Type [NCIt concept]
- Protein Kinase C Beta Type [NCIt concept]
- Solute Carrier Family 12 Member 2 [NCIt concept]
- Tight Junction Protein ZO-1 [NCIt concept]
- V-Type Proton ATPase 116 kDa Subunit A 1 [NCIt concept]
- V-Type Proton ATPase 116 kDa Subunit A 3 [NCIt concept]
- V-Type Proton ATPase Subunit B, Brain Isoform [NCIt concept]
- V-Type Proton ATPase Subunit S1 [NCIt concept]
pathway_has_gene_element
- ACTB wt Allele [NCIt concept]
- ACTG1 wt Allele [NCIt concept]
- ADCY9 wt Allele [NCIt concept]
- ARF1 wt Allele [NCIt concept]
- ATP6AP1 wt Allele [NCIt concept]
- ATP6V0A1 wt Allele [NCIt concept]
- ATP6V1B2 wt Allele [NCIt concept]
- CFTR wt Allele [NCIt concept]
- ERO1A wt Allele [NCIt concept]
- MUC2 wt Allele [NCIt concept]
- PLCG1 wt Allele [NCIt concept]
- PLCG2 wt Allele [NCIt concept]
- PRKCA wt Allele [NCIt concept]
- PRKCB wt Allele [NCIt concept]
- SLC12A2 wt Allele [NCIt concept]
- TCIRG1 wt Allele [NCIt concept]
- TJP1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients