Gonadotropin-Releasing Hormone Signaling Pathway

Preferred Label : Gonadotropin-Releasing Hormone Signaling Pathway;

NCIt related terms : GnRH signaling pathway;

Alternative definition : KEGG: Gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnRHR is coupled to Gq/11 proteins to activate phospholipase C which transmits its signal to diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG activates the intracellular protein kinase C (PKC) pathway and IP3 stimulates release of intracellular calcium. In addition to the classical Gq/11, coupling of Gs is occasionally observed in a cell-specific fashion. Signaling downstream of protein kinase C (PKC) leads to transactivation of the epidermal growth factor (EGF) receptor and activation of mitogen-activated protein kinases (MAPKs), including extracellular-signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 MAPK. Active MAPKs translocate to the nucleus, resulting in activation of transcription factors and rapid induction of early genes.;

KEGG ID : hsa04912;

Details

Origin ID

C91480;

UMLS CUI

C2984292;

Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-3 [NCIt concept]
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-4 [NCIt concept]
- 72 kDa Type IV Collagenase [NCIt concept]
- 85 kDa Calcium-Independent Phospholipase A2 [NCIt concept]
- Adenylate Cyclase Type 9 [NCIt concept]
- Calcium/Calmodulin-Dependent Protein Kinase Type II Subunit Alpha [NCIt concept]
- Calmodulin [NCIt concept]
- Cytosolic Phospholipase A2 [NCIt concept]
- Cytosolic Phospholipase A2 Beta [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 3 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 4 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 6 [NCIt concept]
- ETS Domain-Containing Protein Elk-1 [NCIt concept]
- Epidermal Growth Factor Receptor [NCIt concept]
- Follitropin Subunit Beta [NCIt concept]
- GTPase HRas [NCIt concept]
- GTPase KRas [NCIt concept]
- GTPase Nras [NCIt concept]
- Glycoprotein Hormones Alpha Chain Protein [NCIt concept]
- Gonadoliberin-1 [NCIt concept]
- Gonadoliberin-2 [NCIt concept]
- Gonadotropin-Releasing Hormone Receptor [NCIt concept]
- Growth Factor Receptor-Bound Protein 2 [NCIt concept]
- Heparin-Binding EGF-Like Growth Factor [NCIt concept]
- Inositol 1,4,5-Trisphosphate Receptor Type 1 [NCIt concept]
- Inositol 1,4,5-Trisphosphate Receptor Type 2 [NCIt concept]
- Lutropin Subunit Beta [NCIt concept]
- Matrix Metalloproteinase-14 [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 10 [NCIt concept]
- Mitogen-Activated Protein Kinase 11 [NCIt concept]
- Mitogen-Activated Protein Kinase 12 [NCIt concept]
- Mitogen-Activated Protein Kinase 13 [NCIt concept]
- Mitogen-Activated Protein Kinase 14 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Mitogen-Activated Protein Kinase 7 [NCIt concept]
- Mitogen-Activated Protein Kinase 8 [NCIt concept]
- Mitogen-Activated Protein Kinase 9 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 3 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 4 [NCIt concept]
- Protein Kinase C Alpha Type [NCIt concept]
- Protein Kinase C Beta Type [NCIt concept]
- Protein Kinase C Delta Type [NCIt concept]
- Protein-Tyrosine Kinase 2-Beta [NCIt concept]
- Proto-Oncogene Tyrosine-Protein Kinase Src [NCIt concept]
- Son of Sevenless Homolog 2 [NCIt concept]
- Transcription Factor AP-1 [NCIt concept]
- Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1C [NCIt concept]
- Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1D [NCIt concept]
- Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1S [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Alpha [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Beta [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Gamma [NCIt concept]
pathway_has_gene_element
- ADCY9 wt Allele [NCIt concept]
- CACNA1C wt Allele [NCIt concept]
- CACNA1D wt Allele [NCIt concept]
- CACNA1S wt Allele [NCIt concept]
- CALM1 wt Allele [NCIt concept]
- CAMK2A wt Allele [NCIt concept]
- CGA wt Allele [NCIt concept]
- EGFR wt Allele [NCIt concept]
- ELK1 wt Allele [NCIt concept]
- FSHB wt Allele [NCIt concept]
- GNRH2 wt Allele [NCIt concept]
- GNRHR wt Allele [NCIt concept]
- GRB2 wt Allele [NCIt concept]
- HBEGF wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- ITPR1 wt Allele [NCIt concept]
- ITPR2 wt Allele [NCIt concept]
- JUN wt Allele [NCIt concept]
- KRAS wt Allele [NCIt concept]
- LHB wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAP2K2 wt Allele [NCIt concept]
- MAP2K3 wt Allele [NCIt concept]
- MAP2K4 wt Allele [NCIt concept]
- MAP2K6 wt Allele [NCIt concept]
- MAP3K1 wt Allele [NCIt concept]
- MAP3K3 wt Allele [NCIt concept]
- MAP3K4 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK10 wt Allele [NCIt concept]
- MAPK11 wt Allele [NCIt concept]
- MAPK12 wt Allele [NCIt concept]
- MAPK13 wt Allele [NCIt concept]
- MAPK14 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MAPK7 wt Allele [NCIt concept]
- MAPK8 wt Allele [NCIt concept]
- MAPK9 wt Allele [NCIt concept]
- MMP14 wt Allele [NCIt concept]
- MMP2 wt Allele [NCIt concept]
- NRAS wt Allele [NCIt concept]
- PLA2G4A wt Allele [NCIt concept]
- PLA2G4B wt Allele [NCIt concept]
- PLA2G6 wt Allele [NCIt concept]
- PLCB3 wt Allele [NCIt concept]
- PLCB4 wt Allele [NCIt concept]
- PRKACA wt Allele [NCIt concept]
- PRKACB wt Allele [NCIt concept]
- PRKACG wt Allele [NCIt concept]
- PRKCA wt Allele [NCIt concept]
- PRKCB wt Allele [NCIt concept]
- PRKCD wt Allele [NCIt concept]
- PTK2B wt Allele [NCIt concept]
- SOS2 wt Allele [NCIt concept]
- SRC wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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