" /> Gonadotropin-Releasing Hormone Receptor - CISMeF





Preferred Label : Gonadotropin-Releasing Hormone Receptor;

NCIt synonyms : Luliberin Receptor; GnRH-R; Leutinizing-Releasing Hormone Receptor; Gonadotropin-Releasing Hormone (Type 1) Receptor 1; Type I GnRH Receptor; Leutinizing Hormone Releasing Hormone Receptor; GnRH Receptor; LRHR Receptor; LHRHR; GNRHR; LHRH-R; Leutinizing Hormone-Releasing Hormone Receptor;

NCIt definition : Gonadotropin-releasing hormone receptor (328 aa, 38 kDa) is encoded by the human GNRHR gene. This protein is involved in the regulation of pituitary hormone release and G protein-coupled receptor signaling.;

NCIt note : Expressed as 2 alternative isoforms in pituitary, ovary, testis, breast, and prostate by human GNRHR Gene (GPCR1 Family), Gonadotropin-Releasing Hormone Receptor is a cell surface G protein-coupled 7-transmembrane-domain receptor that transduces signals from hypothalamic decapeptide GNRH by association with G proteins that activate a calcium-phosphatidylinositol second messenger system. A neuroregulator of reproduction, the primary site of GNRH action is pituitary gonadotropes, which express GNRH receptors that modulate synthesis and secretion of gonadotropic hormones LH and FSH, which regulate gametogenic and hormonal functions of gonads. GNRHR Isoform 2 may act as an inhibitor of GNRHR signaling.;

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12/05/2024


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