Goserelin Acetate

Preferred Label : Goserelin Acetate;

NCIt synonyms : D-Ser(bu(t))(6)azgly(10)-LHRH Acetate; ZDX;

NCIt related terms : Zoladex;

NCIt definition : The acetate salt of a synthetic decapeptide analog of luteinizing hormone-releasing hormone (LHRH). Continuous, prolonged administration of goserelin in males results in inhibition of pituitary gonadotropin secretion, leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. (NCI04);

UNII : 6YUU2PV0U8;

InChIKey : IKDXDQDKCZPQSZ-JHYYTBFNSA-N;

CAS number : 65807-02-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 65807-02-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Zoladex;

Chemical formula : C59H84N18O14.C2H4O2;

NSC code : 606864;

Codes from synonyms : NSC0606864;

Details

Origin ID

C1417;

UMLS CUI

C0700476;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Hormone [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_gene_product
- Gonadotropin-Releasing Hormone Receptor [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Receptor Activation Process [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Androgen Activity Inhibition [NCIt concept]
- Endocrine Secretory Inhibition [NCIt concept]
- Estrogen Activity Inhibition [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Goserelin [NCIt concept]
has_target
- Gonadotropin-Releasing Hormone Receptor [NCIt concept]
is_component_of_chemotherapy_regimen
- Abiraterone/Goserelin/Prednisone Regimen [NCIt concept]
- Apalutamide/Goserelin Regimen [NCIt concept]
- Bicalutamide/Goserelin Regimen [NCIt concept]
- Docetaxel/Goserelin Regimen [NCIt concept]
- Enzalutamide/Goserelin Regimen [NCIt concept]
- Goserelin Regimen [NCIt concept]
is_salt_form_of
- Goserelin [NCIt concept]

Keyword's position in hierarchy(ies) :

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