Goserelin Acetate Extended-release Microspheres LY01005

Preferred Label : Goserelin Acetate Extended-release Microspheres LY01005;

NCIt synonyms : LY-01005; Goserelin Acetate Extended-release Microspheres;

NCIt definition : A long-acting, extended-release microsphere formulation of the acetate form of goserelin, a synthetic decapeptide analog of luteinizing hormone-releasing hormone (LHRH), with potential antineoplastic activity. Upon administration, goserelin binds to and activates pituitary gonadotropin-releasing hormone (GnRH) receptors. Prolonged administration of goserelin inhibits the secretion of pituitary gonadotropin, thereby decreasing levels of testosterone (in males) and estradiol (in females). Administration of this agent in an extended-release formulation may result in the regression of sex hormone-sensitive tumors and a reduction in sex organ size and function.;

Molecule name : LY01005; LY 01005;

NCI Metathesaurus CUI : CL935864;

Details

Origin ID

C156710;

UMLS CUI

C4745007;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_gene_product
- Gonadotropin-Releasing Hormone Receptor [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Receptor Activation Process [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Androgen Activity Inhibition [NCIt concept]
- Endocrine Secretory Inhibition [NCIt concept]
- Estrogen Activity Inhibition [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Goserelin [NCIt concept]
is_salt_form_of
- Goserelin [NCIt concept]

Keyword's position in hierarchy(ies) :

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