Degarelix Acetate

Preferred Label : Degarelix Acetate;

NCIt synonyms : FE200486 Acetate Hydrate; D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3- pyridinyl)-D-alanyl-L- seryl-4-[[[(4S)-hexahydro-2,6-dioxo-4-pyrimidinyl]carbonyl]amino]- L-phenylalanyl-4-[(aminocarbonyl)amino]-D-phenylalanyl-L-leucyl-N6-(1-methylethyl)-L- lysyl-L-prolyl, Acetate, Hydrate;

NCIt definition : The acetate form of a long-acting, synthetic peptide with gonadotrophin-releasing hormone (GnRH) antagonistic properties. Degarelix targets and blocks GnRH receptors located on the surfaces of gonadotroph cells in the anterior pituitary, thereby reducing secretion of luteinizing hormone (LH) by pituitary gonadotroph cells and so decreasing testosterone production by interstitial (Leydig) cells in the testes.;

UNII : I18S89P20R;

InChIKey : QMBXFMRFTMPFEY-XDPVAHNXSA-N;

CAS number : 934246-14-7;

Drug name : Gonax;

Chemical formula : C82H103ClN18O16.C2H4O2.H2O;

Détails

Origin ID

C80443;

UMLS CUI

C2718533;

Automatic exact mappings (from CISMeF team)
- acetyl-2-naphthylalanyl-3-chlorophenylalanyl-1-oxohexadecyl-seryl-4-aminophenylalanyl(hydroorotyl)-4-aminophenylalanyl(carbamoyl)-leucyl-ILys-prolyl-alaninamide [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- degarelix [Substance BNPC]
Validated automatic mappings to NTBT
- degarelix [Substance BNPC]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_free_acid_or_base_form
- Degarelix [NCIt concept]
has_target
- Gonadotropin-Releasing Hormone Receptor [NCIt concept]
is_component_of_chemotherapy_regimen
- AAP-D Regimen [NCIt concept]
- Apalutamide/Degarelix Regimen [NCIt concept]
- Bicalutamide/Degarelix Regimen [NCIt concept]
- Degarelix/Docetaxel Regimen [NCIt concept]
- Degarelix/Enzalutamide Regimen [NCIt concept]
is_salt_form_of
- Degarelix [NCIt concept]

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