Ucalolictide - CISMeF

Preferred Label : Ucalolictide;

NCIt synonyms : Membrane-Disrupting Peptide EP-100; Onvitrelin Ucalontide;

NCIt definition : A water-soluble, positively charged fusion protein consisting of a luteinizing hormone releasing hormone (LHRH) receptor-targeting ligand conjugated to the membrane-disrupting peptide CLIP 71 with membrane-disrupting and potential antineoplastic activities. The LHRH ligand moiety of ucalolictide specifically binds to LHRH receptors, which are upregulated on a variety of human cancer cell types. Subsequently, the positively charged CLIP 71 moiety of this agent interacts with the negatively charged membrane on the cancer cell surface, which may result in cell membrane disruption and cell lysis.;

UNII : UF1EL37E41;

CAS number : 1620643-19-7;

Molecule name : EP-100; EP 100;

NCI Metathesaurus CUI : CL412421;

Details

Origin ID

C84860;

UMLS CUI

C5856902;

Automatic exact mappings (from CISMeF team)
- EP-100 membrane-disrupting peptide [MeSH Supplementary Concept]
- EP-100 membrane-disrupting peptide [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- EP-100 membrane-disrupting peptide [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Gonadotropin-Releasing Hormone Receptor [NCIt concept]

Keyword's position in hierarchy(ies) :

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